Monitoring Changes in Clinical Trial Primary Outcomes Using Large Language Models

Published in JAMA Network Open, 2026

Recommended citation: Ian Bulovic, Susmitha Wunnava, Wonjin Yoon, Adam G Dunn, Timothy Miller, and Florence T Bourgeois. 2026. Monitoring Changes in Clinical Trial Primary Outcomes Using Large Language Models. In JAMA Network Open. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854124

Abstract:

This cross-sectional study investigates the prevalence of meaningful changes to the outcomes in preregistered clinical trials using large language models.